TIMP1

Across TCGA pan-cancer cohorts, TIMP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TIMP1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TIMP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TIMP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where TIMP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.583	0.897	<.001	100	view →
CCRCC	DFS	Quartile	II,III,IV	0.370	0.876	.001	44	view →
COAD	DFS	Median	All	0.882	1.000	.016	36	view →
UCEC	DFS	Quartile	All	0.965	0.751	.011	18	view →
GBM	OS	Tertile	All	0.264	0.464	.024	7	view →
LSCC	DFS	Quartile	All	0.912	1.000	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TIMP1–LUAD (OS)

Open the LUAD breakdown →