TIMP1

Across TCGA pan-cancer cohorts, TIMP1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TIMP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TIMP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TIMP1 is over-expressed in tumor.

COAD, LUAD, and PDAC are the cancer types where TIMP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.404	<.001	12	view →
LUAD	All	III,IV	+1.111	<.001	9	view →
PDAC	Male	All	+0.806	<.001	8	view →
LSCC	All	III,IV	+1.006	<.001	7	view →
HNSC	All	IV	+0.638	.002	2	view →
CCRCC	Male	IV	+0.881	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TIMP1–COAD

Open the COAD breakdown →