TIMP1

Across TCGA patient cohorts, TIMP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,030 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TIMP1-associated proteins across cancer lineages are SERPINF1, LUM, and ACTN1. Each is linked with TIMP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TIMP1-to-partner and partner-to-TIMP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TIMP1 versus SERPINF1 in CCRCC, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP1→partner) and Y-score (partner→TIMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SERPINF1 →	+0.992	+0.791	<.001	<.001	3	7
GBM	LUM →	+1.209	+1.233	<.001	<.001	3	7
CCRCC	ACTN1 →	+0.574	+0.750	<.001	<.001	3	7
OV	C1R →	+0.763	+1.057	<.001	<.001	3	7
GBM	C8B →	+0.588	+1.286	<.001	<.001	3	7
OV	AEBP1 →	+0.827	+1.060	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,030 associations by consensus.

TIMP1 vs SERPINF1 — CCRCC

Explore this scatter interactively →