TIMP1

Across TCGA patient cohorts, TIMP1 mutation is significantly associated with the RNA expression of many other genes, with 764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMP1-associated genes across cancer lineages are MIR199B, RN7SL554P, and CCNG1P1. Each is linked with TIMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP1-to-partner and partner-to-TIMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR199B grouped by TIMP1-low versus TIMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP1→partner) and Y-score (partner→TIMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR199B →	+0.165	+2.682	<.001	.004	3	2
UCEC	RN7SL554P →	+0.077	+2.601	.004	.005	3	2
READ	CCNG1P1 →	+0.110	+5.179	.004	.001	3	2
READ	RPL9P15 →	+0.117	+4.925	<.001	.004	3	2
READ	MYLK-AS2 →	+0.175	+4.533	<.001	.004	3	2
SKCM	MTCYBP10 →	+0.028	+4.671	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 764 associations by consensus.

MIR199B by TIMP1 expression — UCEC

Explore this box plot interactively →