TIMM8B

Across TCGA pan-cancer cohorts, TIMM8B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TIMM8B data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TIMM8B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TIMM8B expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where TIMM8B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.922	0.509	<.001	50	view →
LUAD	DFS	Median	II,III,IV	0.970	0.703	.002	27	view →
PDAC	DFS	Tertile	All	0.922	0.733	.023	8	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TIMM8B–LSCC (DFS)

Open the LSCC breakdown →