TIMM8A

Across TCGA patient cohorts, TIMM8A mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM8A-associated genes across cancer lineages are 14-3-3_beta, Fibronectin, and Heregulin. Each is linked with TIMM8A in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM8A-to-partner and partner-to-TIMM8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TIMM8A-low versus TIMM8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM8A→partner) and Y-score (partner→TIMM8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.125	-3.295	.004	.009	3	1
UCEC	Fibronectin →	-0.327	-2.312	.023	.034	3	1
UCEC	Heregulin →	-0.122	-2.321	.023	.034	3	1
UCEC	ACVRL1 →	-0.126	-3.439	.035	.005	3	1
UCEC	Notch1 →	+0.169	+2.807	.005	.003	3	1
UCEC	Akt_pT308 →	+0.612	+2.115	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by TIMM8A expression — UCEC

Explore this box plot interactively →