TIMM50

Across TCGA pan-cancer cohorts, TIMM50 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TIMM50 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TIMM50 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TIMM50 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where TIMM50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.754	0.938	.008	45	view →
HNSC	DFS	Median	II,III,IV	0.890	0.983	.032	9	view →
LSCC	OS	Quartile	All	1.000	0.759	.016	8	view →
LUAD	DFS	Median	All	0.474	0.730	.015	4	view →
PDAC	OS	Quartile	II,III,IV	0.644	0.395	.040	4	view →
GBM	OS	Median	All	0.935	0.778	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TIMM50–CCRCC (OS)

Open the CCRCC breakdown →