TIMM44

Across TCGA pan-cancer cohorts, TIMM44 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TIMM44 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TIMM44 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TIMM44 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where TIMM44 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.866	0.511	<.001	45	view →
PDAC	DFS	Median	III,IV	0.977	0.451	.001	27	view →
CCRCC	DFS	Quartile	All	0.543	0.895	.010	27	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.864	.042	12	view →
HNSC	DFS	Quartile	All	1.000	0.890	.021	3	view →
LUAD	DFS	Quartile	II,III,IV	0.991	0.627	.016	3	view →
GBM	OS	Median	All	0.874	0.760	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TIMM44–LSCC (DFS)

Open the LSCC breakdown →