TIMM23

Across TCGA patient cohorts, TIMM23 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM23-associated genes across cancer lineages are MEK1_p_S217_S221, MSH2, and MSH6. Each is linked with TIMM23 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM23-to-partner and partner-to-TIMM23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by TIMM23-low versus TIMM23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM23→partner) and Y-score (partner→TIMM23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	-0.338	-3.000	.032	.037	3	1
UCEC	MSH2 →	-0.434	-3.000	.001	.037	3	1
UCEC	MSH6 →	-0.664	-3.000	<.001	.037	1	1
UCEC	Annexin-1 →	+0.755	+3.000	.013	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1_p_S217_S221 by TIMM23 expression — UCEC

Explore this box plot interactively →