TIMM23

Across TCGA cell cohorts, TIMM23 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIMM23-associated genes across cancer lineages are SYCN, TSPY3, and IL2. Each is linked with TIMM23 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM23-to-partner and partner-to-TIMM23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYCN grouped by TIMM23-low versus TIMM23-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM23→partner) and Y-score (partner→TIMM23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SYCN →	+0.071	+5.169	<.001	.005	3	1
BREAST	TSPY3 →	+0.067	+5.169	<.001	.005	3	1
BLOOD_Leukemia	IL2 →	+0.982	+4.276	<.001	.007	3	1
BLOOD_Leukemia	SLC17A4 →	+0.079	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR13F1 →	+0.030	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SYCN by TIMM23 expression — BREAST

Explore this box plot interactively →