TIMM21

Across TCGA pan-cancer cohorts, TIMM21 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TIMM21 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TIMM21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIMM21 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where TIMM21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.332	0.881	<.001	34	view →
UCEC	DFS	Median	All	0.840	0.972	.005	12	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	5	view →
LSCC	DFS	Median	II,III,IV	0.852	0.550	.014	5	view →
HNSC	OS	Median	All	1.000	0.960	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TIMM21–LUAD (DFS)

Open the LUAD breakdown →