TIMM21

Across TCGA patient cohorts, TIMM21 mutation is significantly associated with the RNA expression of many other genes, with 2,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM21-associated genes across cancer lineages are MIR6803, SLC5A4P1, and PSAT1P4. Each is linked with TIMM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM21-to-partner and partner-to-TIMM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by TIMM21-low versus TIMM21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM21→partner) and Y-score (partner→TIMM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.172	+4.671	<.001	.002	3	2
BLCA	SLC5A4P1 →	+0.104	+5.588	<.001	.004	3	2
BLCA	PSAT1P4 →	+0.091	+5.038	<.001	.009	3	2
SKCM	RNU6-92P →	+0.347	+3.564	<.001	.005	3	1
UCEC	CCDC163 →	+0.528	+3.353	.002	.005	3	1
COAD	OR4X2 →	+0.054	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,713 associations by consensus.

MIR6803 by TIMM21 expression — UCEC

Explore this box plot interactively →