TIMM21

Across TCGA patient cohorts, TIMM21 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM21-associated genes across cancer lineages are STAT3_pY705, C-Raf, and Ku80. Each is linked with TIMM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM21-to-partner and partner-to-TIMM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TIMM21-low versus TIMM21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM21→partner) and Y-score (partner→TIMM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.500	-3.321	<.001	.009	3	2
UCEC	C-Raf →	+0.156	+3.169	.024	.019	3	2
UCEC	Ku80 →	+0.305	+2.472	.007	.011	3	1
UCEC	p27_pT198 →	+0.133	+3.000	.010	.036	3	1
UCEC	PCNA →	+0.336	+3.584	.001	.002	3	1
UCEC	Raptor →	-0.172	-3.000	.019	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

STAT3_pY705 by TIMM21 expression — UCEC

Explore this box plot interactively →