TIMM10B

Across TCGA pan-cancer cohorts, TIMM10B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TIMM10B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TIMM10B RNA is repressed in tumor relative to normal tissue. In most cancer types TIMM10B is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and THCA are the cancer types where TIMM10B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMM10B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.741	<.001	12	view →
LUAD	Male	III,IV	−0.700	<.001	11	view →
THCA	All	IV	−0.867	<.001	10	view →
LIHC	Female	II,III,IV	+1.033	<.001	9	view →
LUSC	Female	II,III,IV	−0.787	<.001	8	view →
BLCA	All	IV	−0.857	.002	6	view →
KIRP	Male	III,IV	−0.538	<.001	6	view →
CHOL	All	All	+1.497	<.001	5	view →
COAD	Male	All	+0.383	.003	4	view →
HNSC	Male	III,IV	+0.396	.014	3	view →
KICH	Male	All	−0.665	.025	2	view →
UCEC	All	All	−0.656	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TIMM10B–KIRC

Open the KIRC breakdown →