TIMELESS

Across TCGA pan-cancer cohorts, TIMELESS mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TIMELESS’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TIMELESS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TIMELESS is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, OV, and PDAC are the cancer types where TIMELESS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMELESS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.785	<.001	8	view →
OV	All	All	+0.681	.009	2	view →
PDAC	All	All	−0.594	.041	2	view →
CCRCC	Male	All	+0.497	.001	1	view →
LUAD	Male	All	+0.243	.028	1	view →
HNSC	Male	All	+0.161	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TIMELESS–LSCC

Open the LSCC breakdown →