TIMELESS

Across TCGA cell cohorts, TIMELESS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,862 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIMELESS-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Regulation of double-strand break repair, and Mitotic DNA damage checkpoint signaling. Each is linked with TIMELESS in more than 19 cancer types. Because this analysis shows association rather than direction, both TIMELESS-to-partner and partner-to-TIMELESS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by TIMELESS-low versus TIMELESS-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMELESS→partner) and Y-score (partner→TIMELESS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.102	+1.579	<.001	<.001	3	20
SOFT_TISSUE	Regulation of double-strand break repair →	+0.081	+1.650	<.001	<.001	3	20
SOFT_TISSUE	Mitotic DNA damage checkpoint signaling →	+0.108	+1.643	<.001	<.001	3	20
LUNG_SCLC	Regulation of centrosome cycle →	+0.120	+0.820	<.001	.001	3	20
OESOPHAGUS	DNA-templated DNA replication →	+0.164	+1.668	<.001	<.001	3	20
SOFT_TISSUE	Regulation of DNA repair →	+0.079	+1.631	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,862 associations by consensus.

Regulation of double-strand break repair via homologous recombination by TIMELESS expression — SOFT_TISSUE

Explore this box plot interactively →