TIMELESS

Across TCGA cell cohorts, TIMELESS mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIMELESS-associated genes across cancer lineages are SPACA5B, OR2T29, and OR2T10. Each is linked with TIMELESS in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMELESS-to-partner and partner-to-TIMELESS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA5B grouped by TIMELESS-low versus TIMELESS-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMELESS→partner) and Y-score (partner→TIMELESS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPACA5B →	+0.657	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR2T29 →	+0.642	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR2T10 →	+0.036	+5.369	<.001	.004	3	1
BLOOD_Myeloma	KRT79 →	+0.016	+4.321	.001	<.001	3	1
BREAST	PRLH →	+0.425	+4.421	.004	.004	3	1
BLOOD_Leukemia	DPP6 →	+0.253	+2.886	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SPACA5B by TIMELESS expression — SOFT_TISSUE

Explore this box plot interactively →