TIMD4

Across TCGA patient cohorts, TIMD4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMD4-associated genes across cancer lineages are p27_pT198, Cyclin-B1, and p27. Each is linked with TIMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMD4-to-partner and partner-to-TIMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by TIMD4-low versus TIMD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMD4→partner) and Y-score (partner→TIMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.089	+1.584	.034	.036	3	2
UCEC	Cyclin-B1 →	+0.489	+3.321	.026	.009	3	2
LUSC	p27 →	-0.204	-2.990	.013	.036	3	1
LUSC	PREX1 →	-0.313	-2.986	.001	.035	3	1
LUSC	4E-BP1_pS65 →	+0.288	+3.009	<.001	.019	3	1
LUAD	Bcl-xL →	-0.219	-2.987	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p27_pT198 by TIMD4 expression — UCEC

Explore this box plot interactively →