TIGIT

Across TCGA patient cohorts, TIGIT mutation is significantly associated with the RNA expression of many other genes, with 1,572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGIT-associated genes across cancer lineages are TUBB8P5, GSTO1, and TEX30. Each is linked with TIGIT in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGIT-to-partner and partner-to-TIGIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB8P5 grouped by TIGIT-low versus TIGIT-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGIT→partner) and Y-score (partner→TIGIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TUBB8P5 →	+0.048	+5.039	<.001	.008	3	2
SKCM	GSTO1 →	+0.985	+3.328	<.001	.005	3	2
SKCM	TEX30 →	+0.855	+3.353	.003	.005	3	2
UCEC	FAM177A1 →	+0.338	+3.202	.009	.009	3	2
UCEC	ZNF367 →	+0.724	+3.343	.001	.005	3	2
UCEC	GHITM →	+0.625	+3.513	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,572 associations by consensus.

TUBB8P5 by TIGIT expression — READ

Explore this box plot interactively →