TIGIT

Across TCGA cell cohorts, TIGIT mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIGIT-associated genes across cancer lineages are DEFA4, TBC1D21, and CHRNA2. Each is linked with TIGIT in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGIT-to-partner and partner-to-TIGIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by TIGIT-low versus TIGIT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGIT→partner) and Y-score (partner→TIGIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CHRNA2 →	+0.067	+3.453	.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFA4 by TIGIT expression — LARGE_INTESTINE

Explore this box plot interactively →