TIGD7

Across TCGA patient cohorts, TIGD7 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD7-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and IGFBP2. Each is linked with TIGD7 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIGD7-to-partner and partner-to-TIGD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by TIGD7-low versus TIGD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD7→partner) and Y-score (partner→TIGD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.145	+1.807	.003	.025	3	3
UCEC	EGFR_pY1068 →	-0.253	-3.807	.003	<.001	3	2
UCEC	IGFBP2 →	-0.510	-1.874	.023	.049	3	2
UCEC	Notch1 →	+0.132	+1.713	.006	.024	3	2
UCEC	PDCD4 →	-0.472	-2.321	.003	.033	3	2
UCEC	ATM →	-0.401	-2.321	.010	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

C-Raf by TIGD7 expression — UCEC

Explore this box plot interactively →