TIGD5

Across TCGA patient cohorts, TIGD5 mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TIGD5-associated genes across cancer lineages are GIMD1, RPS27P20, and RNA5SP519. Each is linked with TIGD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD5-to-partner and partner-to-TIGD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMD1 grouped by TIGD5-low versus TIGD5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD5→partner) and Y-score (partner→TIGD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GIMD1 →	+0.293	+5.680	<.001	.003	3	2
LIHC	RPS27P20 →	+0.154	+4.350	<.001	.002	3	2
LIHC	RNA5SP519 →	+0.192	+5.091	<.001	.003	3	2
UCEC	RNA5SP199 →	+0.802	+3.677	<.001	.006	3	2
SKCM	RSL24D1P4 →	+0.080	+5.224	.003	.007	3	2
SCLC	NPVF →	+0.043	+4.847	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

GIMD1 by TIGD5 expression — SKCM

Explore this box plot interactively →