TIGD5

Across TCGA cell cohorts, TIGD5 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIGD5-associated genes across cancer lineages are CCDC140, TMEM114, and TBL1Y. Each is linked with TIGD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD5-to-partner and partner-to-TIGD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC140 grouped by TIGD5-low versus TIGD5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD5→partner) and Y-score (partner→TIGD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC140 →	+0.083	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	CPLX4 →	+0.027	+4.392	.001	.004	3	1
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CCDC140 by TIGD5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →