TIGD2

Across TCGA patient cohorts, TIGD2 mutation is significantly associated with the RNA expression of many other genes, with 4,375 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD2-associated genes across cancer lineages are RNA5SP70, MIR6803, and TRMU. Each is linked with TIGD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD2-to-partner and partner-to-TIGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP70 grouped by TIGD2-low versus TIGD2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD2→partner) and Y-score (partner→TIGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP70 →	+0.459	+7.930	<.001	.008	3	2
UCEC	MIR6803 →	+0.150	+4.539	<.001	<.001	3	2
UCEC	TRMU →	+0.544	+2.459	<.001	<.001	3	2
UCEC	RNA5SP176 →	+0.295	+3.306	<.001	.003	3	2
UCEC	RFKP1 →	+0.072	+2.171	.002	.006	3	2
UCEC	RN7SKP181 →	+0.080	+2.063	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,375 associations by consensus.

RNA5SP70 by TIGD2 expression — LUAD

Explore this box plot interactively →