TIGD2

Across TCGA patient cohorts, TIGD2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD2-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and A-Raf_pS299. Each is linked with TIGD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD2-to-partner and partner-to-TIGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TIGD2-low versus TIGD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD2→partner) and Y-score (partner→TIGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.333	-3.392	<.001	<.001	3	1
UCEC	eIF4G →	+0.313	+2.115	.005	.017	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.807	.004	.003	3	1
UCEC	ERK2 →	+0.222	+2.584	.001	.010	3	1
UCEC	FoxM1 →	+0.254	+2.247	.007	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.096	-1.668	.036	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

EGFR_pY1068 by TIGD2 expression — UCEC

Explore this box plot interactively →