TIGD2

Across TCGA cell cohorts, TIGD2 mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIGD2-associated genes across cancer lineages are 123829, Sabutoclax, and KRAS (G12C) Inhibitor-12. Each is linked with TIGD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD2-to-partner and partner-to-TIGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 123829 grouped by TIGD2-low versus TIGD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD2→partner) and Y-score (partner→TIGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	123829 →	+0.615	+2.649	.034	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.419	+2.769	.049	.040	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.564	+2.646	.023	.047	3	1
LARGE_INTESTINE	PRT062607 →	+0.628	+2.769	.012	.040	2	1
LARGE_INTESTINE	Uprosertib →	+0.734	+2.646	.014	.047	1	1
LARGE_INTESTINE	CDK9_5038 →	+0.674	+2.906	.013	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

123829 by TIGD2 expression — LARGE_INTESTINE

Explore this box plot interactively →