Across TCGA patient cohorts, TIGD1 mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD1-associated genes across cancer lineages are CYP27B1, UPK1B, and PLAAT1. Each is linked with TIGD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD1-to-partner and partner-to-TIGD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD1→partner) and Y-score (partner→TIGD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYP27B1 →	+0.637	+2.617	<.001	.006	3	1
UCEC	UPK1B →	-2.855	-3.700	<.001	.001	3	1
UCEC	PLAAT1 →	-1.480	-3.689	<.001	.001	3	1
UCEC	PGPEP1 →	+0.650	+3.329	<.001	.005	3	1
UCEC	AOC2 →	+1.110	+3.467	<.001	.002	3	1
UCEC	CD101 →	+0.614	+2.617	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

Exploration

TIGD1 survival (RNA) · tumor vs normal (RNA) · all TIGD1 data types