Across TCGA patient cohorts, TIGD1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD1-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Heregulin. Each is linked with TIGD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD1-to-partner and partner-to-TIGD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD1→partner) and Y-score (partner→TIGD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.195	-3.000	.001	.036	3	1
UCEC	ERK2 →	+0.207	+2.321	.032	.035	3	1
UCEC	Heregulin →	-0.174	-3.156	.005	.018	3	1
UCEC	MEK1 →	+0.432	+3.000	.018	.036	3	1
UCEC	mTOR_pS2448 →	-0.163	-2.321	.029	.035	3	1
UCEC	mTOR →	-0.168	-2.321	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

TIGD1 survival (RNA) · tumor vs normal (RNA) · all TIGD1 data types