TIFA

Across TCGA pan-cancer cohorts, TIFA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TIFA data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TIFA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TIFA expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where TIFA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.866	0.518	.002	47	view →
HNSC	DFS	Tertile	All	0.902	1.000	.009	7	view →
PDAC	OS	Median	All	0.499	0.276	.012	6	view →
CCRCC	OS	Quartile	All	1.000	0.812	.019	3	view →
GBM	OS	Median	All	0.247	0.644	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TIFA–LUAD (DFS)

Open the LUAD breakdown →