TIFA

Across TCGA patient cohorts, TIFA protein abundance is significantly associated with the RNA expression of many other genes, with 9,691 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TIFA-associated genes across cancer lineages are IL4I1, NKG7, and CXCL10. Each is linked with TIFA in more than 5 cancer types. Because this analysis shows association rather than direction, both TIFA-to-partner and partner-to-TIFA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TIFA versus IL4I1 in OV, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIFA→partner) and Y-score (partner→TIFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL4I1 →	+1.104	+0.613	.002	.001	3	6
OV	NKG7 →	+1.526	+0.758	<.001	.001	3	6
OV	CXCL10 →	+2.046	+0.730	<.001	<.001	3	6
GBM	CD247 →	+0.927	+0.943	.007	.009	3	6
HNSC	TNFSF13B →	+0.903	+0.341	<.001	<.001	3	5
UCEC	CORO1A →	+1.158	+0.362	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,691 associations by consensus.

TIFA vs IL4I1 — OV

Explore this scatter interactively →