TIFA

Across TCGA cell cohorts, TIFA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,300 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIFA-associated GO terms across cancer lineages are CMP biosynthetic process, Regulation of chromosome segregation, and Regulation of mitotic metaphase/anaphase transition. Each is linked with TIFA in more than 9 cancer types. Because this analysis shows association rather than direction, both TIFA-to-partner and partner-to-TIFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP biosynthetic process grouped by TIFA-low versus TIFA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIFA→partner) and Y-score (partner→TIFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CMP biosynthetic process →	+0.127	+0.811	.002	.005	3	10
LUNG_SCLC	Regulation of chromosome segregation →	+0.078	+0.989	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.092	+0.689	.005	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.095	+0.695	.003	.004	3	9
PANCREAS	DAMP biosynthetic process →	+0.140	+0.618	<.001	<.001	2	10
PANCREAS	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.140	+0.618	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,300 associations by consensus.

CMP biosynthetic process by TIFA expression — BONE

Explore this box plot interactively →