TICAM1

Across TCGA pan-cancer cohorts, TICAM1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TICAM1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TICAM1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TICAM1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where TICAM1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TICAM1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.734	<.001	11	view →
HNSC	Male	III,IV	−0.190	.027	3	view →
LSCC	All	II,III,IV	+0.107	.021	3	view →
PDAC	Female	All	+0.387	.006	2	view →
LUAD	Male	III,IV	−0.228	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TICAM1–CCRCC

Open the CCRCC breakdown →