TICAM1

Across TCGA patient cohorts, TICAM1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TICAM1-associated genes across cancer lineages are ATM, eIF4E, and FOXO3a_pS318_S321. Each is linked with TICAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TICAM1-to-partner and partner-to-TICAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TICAM1-low versus TICAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TICAM1→partner) and Y-score (partner→TICAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.593	-2.058	<.001	<.001	3	3
UCEC	eIF4E →	+0.179	+3.598	.007	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.104	-1.990	.008	.002	3	2
UCEC	ACC1 →	+0.250	+1.598	.031	.040	3	2
UCEC	MSH6 →	-0.377	-2.087	<.001	.004	3	2
COAD	PDCD4 →	-0.575	-2.991	.008	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by TICAM1 expression — UCEC

Explore this box plot interactively →