TIAM2

Across TCGA patient cohorts, TIAM2 mutation is significantly associated with the RNA expression of many other genes, with 4,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIAM2-associated genes across cancer lineages are LAP3P2, ZIC2, and EXOSC10. Each is linked with TIAM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TIAM2-to-partner and partner-to-TIAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAP3P2 grouped by TIAM2-low versus TIAM2-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM2→partner) and Y-score (partner→TIAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	LAP3P2 →	+0.047	+4.372	<.001	.007	3	4
UCEC	ZIC2 →	+1.209	+1.472	<.001	<.001	3	4
LUAD	EXOSC10 →	+0.610	+3.471	<.001	.002	3	4
UCEC	EIF2S1 →	+0.357	+1.595	.001	.001	3	4
UCEC	PSAT1 →	+0.561	+1.539	.006	.004	3	4
UCEC	ATP6V1B2 →	+0.275	+1.526	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,347 associations by consensus.

LAP3P2 by TIAM2 expression — LGG

Explore this box plot interactively →