TIAM2

Across TCGA patient cohorts, TIAM2 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIAM2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, c-Kit, and FASN. Each is linked with TIAM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TIAM2-to-partner and partner-to-TIAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by TIAM2-low versus TIAM2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM2→partner) and Y-score (partner→TIAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	p38-MAPK_pT180_Y182 →	-0.560	-3.163	.001	.020	3	3
BRCA	c-Kit →	-0.751	-3.169	.006	.020	3	3
UCEC	FASN →	+0.218	+1.241	.035	.012	3	3
UCEC	mTOR_pS2448 →	-0.103	-1.794	.008	.003	3	3
UCEC	Notch1 →	+0.102	+1.280	.005	.003	3	3
COAD	PDCD4 →	-0.444	-2.576	.011	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

p38-MAPK_pT180_Y182 by TIAM2 expression — BRCA

Explore this box plot interactively →