TIAM2

Across TCGA cell cohorts, TIAM2 mutation is significantly associated with the mutation status of many other genes, with 5,806 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIAM2-associated genes across cancer lineages are WNK1, SPTBN2, and PHF20L1. Each is linked with TIAM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TIAM2-to-partner and partner-to-TIAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WNK1 grouped by TIAM2-low versus TIAM2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM2→partner) and Y-score (partner→TIAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WNK1 →	+3.532	+3.357	.005	.005	1	5
BLOOD_Leukemia	SPTBN2 →	+2.209	+2.544	.002	.002	1	5
SKIN	PHF20L1 →	+5.117	+3.977	.001	.001	1	5
LARGE_INTESTINE	SCRIB →	+1.925	+2.378	<.001	<.001	1	5
LARGE_INTESTINE	GRM7 →	+2.118	+2.118	.001	.001	1	5
BLOOD_Leukemia	GTF3C1 →	+2.209	+2.544	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,806 associations by consensus.

WNK1 by TIAM2 expression — SKIN

Explore this box plot interactively →