TIAM1

Across TCGA pan-cancer cohorts, TIAM1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TIAM1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TIAM1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TIAM1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where TIAM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.344	.009	24	view →
CCRCC	OS	Quartile	All	1.000	0.774	.013	7	view →
UCEC	DFS	Quartile	All	1.000	0.896	.037	2	view →
GBM	DFS	Quartile	All	0.474	0.257	.017	2	view →
LSCC	OS	Median	All	0.880	0.745	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TIAM1–HNSC (OS)

Open the HNSC breakdown →