TIAM1

Across TCGA patient cohorts, TIAM1 mutation is significantly associated with the RNA expression of many other genes, with 8,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIAM1-associated genes across cancer lineages are VAPA, MCM10, and SDHA. Each is linked with TIAM1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TIAM1-to-partner and partner-to-TIAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAPA grouped by TIAM1-low versus TIAM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM1→partner) and Y-score (partner→TIAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VAPA →	+0.328	+1.925	.002	.004	3	5
LUSC	MCM10 →	+0.489	+2.181	.004	.002	3	5
LUSC	SDHA →	+0.431	+3.071	<.001	<.001	3	5
UCEC	C18orf32 →	+0.309	+1.465	<.001	<.001	3	5
SKCM	KIF2C →	+0.616	+2.584	<.001	<.001	3	5
COAD	ZBTB8A →	+0.364	+2.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,515 associations by consensus.

VAPA by TIAM1 expression — COAD

Explore this box plot interactively →