TIAM1

Across TCGA patient cohorts, TIAM1 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIAM1-associated genes across cancer lineages are eIF4E, GAPDH, and Caspase-7-cleavedD198. Each is linked with TIAM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TIAM1-to-partner and partner-to-TIAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TIAM1-low versus TIAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM1→partner) and Y-score (partner→TIAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+2.887	<.001	<.001	3	4
LUSC	GAPDH →	+0.757	+3.169	.002	.017	3	4
STAD	Caspase-7-cleavedD198 →	+0.591	+1.999	.024	.009	3	4
UCEC	MEK1 →	+0.379	+1.404	<.001	<.001	3	3
LUSC	PI3K-p85 →	-0.165	-2.312	.005	.006	3	3
STAD	eEF2 →	+0.335	+1.999	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

eIF4E by TIAM1 expression — UCEC

Explore this box plot interactively →