TIAM1

Across TCGA cell cohorts, TIAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,512 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIAM1-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Negative regulation of RNA splicing, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with TIAM1 in more than 12 cancer types. Because this analysis shows association rather than direction, both TIAM1-to-partner and partner-to-TIAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by TIAM1-low versus TIAM1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM1→partner) and Y-score (partner→TIAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of gene expression, epigenetic →	+0.048	+1.186	<.001	<.001	3	13
PANCREAS	Negative regulation of RNA splicing →	+0.085	+2.184	<.001	<.001	3	11
PANCREAS	Negative regulation of mRNA splicing, via spliceosome →	+0.082	+1.859	.001	<.001	2	12
OVARY	Heterochromatin organization →	+0.083	+1.982	<.001	<.001	3	11
OESOPHAGUS	RNA export from nucleus →	+0.140	+2.309	.002	<.001	3	11
LUNG_NSCLC_LUSC	Protein-DNA complex organization →	+0.063	+1.647	.001	.002	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,512 associations by consensus.

Negative regulation of gene expression, epigenetic by TIAM1 expression — OVARY

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