TIAM1

Across TCGA cell cohorts, TIAM1 mutation is significantly associated with the RNA expression of many other genes, with 715 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIAM1-associated genes across cancer lineages are PRR23A, DYTN, and TGFBI. Each is linked with TIAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIAM1-to-partner and partner-to-TIAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23A grouped by TIAM1-low versus TIAM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM1→partner) and Y-score (partner→TIAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRR23A →	+0.025	+2.786	<.001	.007	3	3
URINARY_TRACT	DYTN →	+0.012	+4.044	<.001	.001	3	2
SKIN	TGFBI →	-3.151	-3.169	.001	.009	3	2
SKIN	TMCO1 →	-1.057	-3.192	<.001	.006	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	2
LARGE_INTESTINE	FBXW7 →	+0.477	+3.459	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 715 associations by consensus.

PRR23A by TIAM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →