TIAL1

Across TCGA pan-cancer cohorts, TIAL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TIAL1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TIAL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TIAL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where TIAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.828	0.929	.026	16	view →
CCRCC	DFS	Tertile	IV	0.887	0.238	.024	9	view →
GBM	OS	Median	All	0.548	0.246	.016	5	view →
PDAC	OS	Median	IV	0.491	0.836	.024	4	view →
LUAD	OS	Quartile	III,IV	1.000	0.447	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TIAL1–HNSC (OS)

Open the HNSC breakdown →