TIAL1

Across TCGA cell cohorts, TIAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,626 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIAL1-associated GO terms across cancer lineages are Regulation of sister chromatid cohesion, Negative regulation of binding, and Viral translational termination-reinitiation. Each is linked with TIAL1 in more than 17 cancer types. Because this analysis shows association rather than direction, both TIAL1-to-partner and partner-to-TIAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sister chromatid cohesion grouped by TIAL1-low versus TIAL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAL1→partner) and Y-score (partner→TIAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of sister chromatid cohesion →	+0.139	+0.781	.003	<.001	3	18
BONE	Negative regulation of binding →	+0.128	+0.671	<.001	.005	3	17
LUNG_SCLC	Viral translational termination-reinitiation →	+0.098	+0.886	<.001	<.001	3	16
CNS	Positive regulation of maintenance of sister chromatid cohesion →	+0.082	+0.481	<.001	<.001	3	15
CNS	Positive regulation of maintenance of mitotic sister chromatid cohesion →	+0.082	+0.481	<.001	<.001	3	15
BONE	Positive regulation of chromosome organization →	+0.095	+0.623	.006	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,626 associations by consensus.

Regulation of sister chromatid cohesion by TIAL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →