TIAL1

Across TCGA cell cohorts, TIAL1 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIAL1-associated genes across cancer lineages are DEFB108B, OR10T2, and GUCA2A. Each is linked with TIAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIAL1-to-partner and partner-to-TIAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by TIAL1-low versus TIAL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAL1→partner) and Y-score (partner→TIAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFB108B →	+0.161	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.071	+4.539	<.001	.007	3	1
LARGE_INTESTINE	SLC25A35 →	+0.809	+3.067	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

DEFB108B by TIAL1 expression — BLOOD_Leukemia

Explore this box plot interactively →