THYN1

Across TCGA patient cohorts, THYN1 mutation is significantly associated with the RNA expression of many other genes, with 1,795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THYN1-associated genes across cancer lineages are RPSAP65, PPP1R2P2, and LINC02662. Each is linked with THYN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THYN1-to-partner and partner-to-THYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP65 grouped by THYN1-low versus THYN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THYN1→partner) and Y-score (partner→THYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPSAP65 →	+0.144	+5.020	<.001	<.001	3	2
SKCM	PPP1R2P2 →	+0.320	+3.875	<.001	.008	3	2
SKCM	LINC02662 →	+0.189	+5.356	<.001	<.001	3	2
CESC	RNU6-517P →	+0.320	+5.201	<.001	.007	3	2
SKCM	SOD1P2 →	+0.061	+4.385	<.001	.008	3	2
UCEC	SETP4 →	+0.105	+2.319	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,795 associations by consensus.

RPSAP65 by THYN1 expression — COAD

Explore this box plot interactively →