THYN1

Across TCGA patient cohorts, THYN1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THYN1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MEK1. Each is linked with THYN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THYN1-to-partner and partner-to-THYN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by THYN1-low versus THYN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THYN1→partner) and Y-score (partner→THYN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.276	-3.169	.028	.019	3	1
UCEC	ERK2 →	+0.227	+2.321	.018	.035	3	1
UCEC	MEK1 →	+0.437	+2.321	.017	.035	3	1
UCEC	P-Cadherin →	-0.194	-2.308	.007	.036	3	1
UCEC	PDK1_pS241 →	+0.198	+3.169	.021	.019	3	1
UCEC	Shc_pY317 →	-0.246	-2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by THYN1 expression — UCEC

Explore this box plot interactively →