THY1

Across TCGA pan-cancer cohorts, THY1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated THY1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher THY1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THY1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where THY1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.618	0.897	<.001	20	view →
UCEC	DFS	Tertile	All	0.743	0.944	.009	18	view →
CCRCC	OS	Median	All	0.944	0.755	.005	12	view →
LUAD	DFS	Tertile	All	0.959	0.796	.009	4	view →
PDAC	DFS	Tertile	III,IV	0.122	0.511	.032	2	view →
GBM	OS	Quartile	All	0.315	0.696	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

THY1–LSCC (DFS)

Open the LSCC breakdown →