THY1

Across TCGA patient cohorts, THY1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THY1-associated genes across cancer lineages are AMPK_pT172, Rictor_pT1135, and Tuberin. Each is linked with THY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THY1-to-partner and partner-to-THY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by THY1-low versus THY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THY1→partner) and Y-score (partner→THY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_pT172 →	+0.511	+3.013	.031	.019	3	1
UCEC	Rictor_pT1135 →	-0.129	-3.000	.029	.037	3	1
UCEC	Tuberin →	+0.546	+3.009	<.001	.019	3	1
UCEC	YB-1_pS102 →	-0.215	-3.000	.044	.037	3	1
UCEC	CDK1_pY15 →	+0.262	+3.021	.029	.019	3	1
UCEC	Akt →	+0.316	+3.000	.016	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

AMPK_pT172 by THY1 expression — UCEC

Explore this box plot interactively →