THUMPD2

Across TCGA pan-cancer cohorts, THUMPD2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of THUMPD2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where THUMPD2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types THUMPD2 is over-expressed in tumor.

LSCC, CCRCC, and LUAD are the cancer types where THUMPD2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THUMPD2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.327	<.001	7	view →
CCRCC	Male	All	+0.277	<.001	7	view →
LUAD	Female	All	+0.318	<.001	6	view →
HNSC	All	All	+0.313	.037	2	view →
PDAC	Female	All	+0.258	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

THUMPD2–LSCC

Open the LSCC breakdown →