THSD4-AS1

Across TCGA pan-cancer cohorts, THSD4-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated THSD4-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher THSD4-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated THSD4-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

BRCA, ESCA, and MESO are the cancer types where THSD4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.866	0.671	<.001	67	view →
ESCA	OS	Quartile	III,IV	0.712	0.310	.003	35	view →
MESO	OS	Tertile	III,IV	0.395	0.613	.009	27	view →
LIHC	OS	Tertile	II,III,IV	0.914	0.686	.007	22	view →
ACC	DFS	Tertile	IV	0.657	0.202	.021	18	view →
LGG	DFS	Quartile	All	0.911	0.775	.003	15	view →
STAD	OS	Quartile	IV	0.673	0.117	.029	12	view →
KIRC	DFS	Quartile	IV	0.290	0.535	.008	12	view →
DLBC	DFS	Tertile	IV	0.195	0.923	.038	10	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	9	view →
READ	OS	Tertile	III,IV	1.000	0.857	.045	9	view →
TGCT	DFS	Median	III,IV	0.604	1.000	.044	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

THSD4-AS1–BRCA (DFS)

Open the BRCA breakdown →